Pharmaceutical Emulsions

Pharmaceutical emulsions are dispersed systems in which one liquid phase is distributed as fine droplets within another immiscible liquid phase. They are widely used in pharmaceutical formulations such as fat emulsions, injectable emulsions, lipid-based drug delivery systems, and other emulsion-based products.

High pressure homogenization is commonly used for droplet size reduction, dispersion, and improved emulsion uniformity. Processing pressure, chamber configuration, formulation composition, and the number of passes can influence the final droplet size and particle size distribution.

NanoGenizer is a laboratory-scale high pressure homogenizer that can be used for pharmaceutical emulsion development. Typical processing conditions for different emulsion systems are shown below.

Emulsions	Oil in water emulsions	Water in oil emulsions	Oil emulsion	Food	Liposome (o/w)	Liposome (w/o)
Sample	Fat emulsion	Cosmetics	Fuel	Milk	DOX	DNA|lipopolyplex
Pressure	~20,000psi	~10,000psi	~20,000psi	~10,000psi	~20,000psi	~8,000psi
Chamber	F20Y, F12Y	F20Y	F20Y, F12Y	F20Y	F20Y, F12Y	F20Y