| Description: |
Genizer provides solutions for nanoemulsions, suitable for batch preparation from 25mL to 10L, or continuous manufacturing from 10mL/min to 20L/hour.
While sonication is effective for small-batch nanoemulsions, it is not especially suitable for processing large quantities of certain types of tissues.
The NanoGenizer, a high-pressure homogenizer, is able to produce nanoemulsions though the combined forces of microfluidization and shear. NanoGenizer maximizes particle reduction, speeds up processing, and lowers the time and overall cost of production.
Not only can high-pressure homogenizers be used for large-batch production of nanoemulsions, they can be set up as part of an inline process, allowing mixing, homogenization, and sterilization of large volumes of nanoemulsions without interruption. |
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| Application: |
Nanoemulsions provide advantages for extract oil and active ingredients with low bioavailability by:
① Increasing bioavailability and reducing response time, dose and adverse effects.
② Masking the taste of the extract oil.
③ Producing translucent droplet sizes of less than 100nm.
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| Performance: |
| Genizer offers the NanoGenizer high-pressure homogenizer for preparation and online sterile filtering for the sterilization of nanoemulsions without interruption. In addition, Genizer also provides the light scattering particle sizer for measuring the size of nanoemulsions. |
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High Pressure Homogenizers
 
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Inline Sterile Filter and Nano Particle Sizer
 
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Recommendation for Nanoemulsions
| Batch |
Recommendation |
| 20mL-5L |
NanoGenizer; 47mm sterile inline filter; Dual Nanoparticle sizer |
| 20mL-5L |
NanoGenizer; 90mm sterile inline filter; Dual Nanoparticle sizer |
| 20mL-10L |
NanoGenizer Dual; 90mm sterile inline filter; Dual Nanoparticle sizer |
| 20mL-30L |
PilotGenizer; 142mm sterile inline filter; Dual Nanoparticle sizer |
| 20mL-50L |
PilotGenizer Dual; 142mm sterile inline filter; Dual Nanoparticle sizer |
| >50L |
Please request quote |
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Disassemble the seal
Assemble the seal
Troubleshooting:
Our design has minimized the occurrence of air-blocking, chamber-blocking and overload.
However, the improper operation of the homogenizer can still induce errors and cause damage to the homogenizer.
Air Blocking
Symptom: there is no pressure and no sucking from inlet
Prevention: do not run with empty inlet
Reason: there is air inside the pump
Solutions:
1) In the customer setup, press the "Degas" button
2) Running 50mL water with 50% speed
3) Push the ball into the inlet valve with a pin
Chamber Blocking
Symptom: overload of the pressure
Prevention: pre-treat the sample carefully; reduce the speed
Reason: there are aggregates or particles in the sample; too high a speed
Solutions:
1) Reverse flow the outlet valve with 100mL water with low speed
2) Reverse flow the chamber with water from low to high speed
Overload
Solutions:
1) Reduce the speed and close the power, wait 30 sec and restart
2) Wash with water or solvent
3) Run with clean and homo-disperse sample
No Response
Symptom: the equipment does not respond when clicking the “Start” button on the touch screen
Solutions:
1) Turn off the power supply and wait for 30 seconds to restart
2) If there is still no response, please check the power input. The power supply of the equipment is 220V. When the external power supply is 110V, a power converter shall be used. And its INPUT port should connect to 110V while the OUTPUT port connect to 220V
Air blocking rarely causes damage to the NanoGenizer; however, the chamber blocking is harmful to the pump because of overloaded pressure in an instant.
1) Pretreat the sample carefully, and always use a clean and homo-disperse sample
2) Adjust the pressure from low to high
3) For safety, do not point the inlet or outlet of high pressure devices and equipment supplied by Genizer, including high pressure homogenizers, extruders, interaction chambers and valves, at any personnel or object that may affect safety or cause property loss.
Tips:
To enhance user applications, we provide a range of choices for inlet and outlet reservoirs for the NanoGenizer.
PRESSURE AND CHAMBER SELECTION FOR VARIOUS APPLICATIONS with NANOGENIZER
| Cells |
Mammalian cell
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Insect cell |
Bacteria cell |
Yeast cell |
Algae cell |
Spore
 |
| Sample |
CHO|Hela |
Sf9|Sf21|H5 |
E. Coli |
Yeast |
Green algae |
Ganoderma |
| Pressure |
600-800bar 8500-11500psi |
600-1000bar 8500-14500psi |
800-1000bar 11500-14500psi |
1200-1400bar 17500-20000psi |
1200-1500bar 7500-21500psi |
1300-1600bar 18500-23000psi |
| Chamber |
F20Y, F20Y-RT |
F20Y, F20Y-RT |
F20Y, F20Y-RT |
F20Y, F12Y |
F20Y, F12Y |
F20Y, F12Y |
| Emulsions |
Oil in water emulsions
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Water in oil emulsions |
Oil emulsion |
Food |
Liposome (o/w) |
Liposome (w/o)
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| Sample |
Fat emulsion |
Cosmetics |
Fuel |
Milk |
DOX |
DNA|lipopolyplex |
| Pressure |
~20,000psi |
~10,000psi |
~20,000psi |
~10,000psi |
~20,000psi |
~8,000psi |
| Chamber |
F20Y, F12Y |
F20Y |
F20Y, F12Y |
F20Y |
F20Y, F12Y |
F20Y |
| Dispersions |
Pigments
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Creams |
Battery |
Particle aggregation |
Graphene |
Nanotubes
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| Sample |
Inks, Coatings |
Creams |
Lithium/Solar cell |
Nano fibril |
Graphene |
Carbon Nanotubes |
| Pressure |
~25,000psi |
~20,000psi |
~20,000psi |
~25,000psi |
~20,000psi |
~20,000psi |
| Chamber |
F20Y, F12Y |
F20Y, F12Y |
F20Y, F12Y |
F20Y, F12Y |
F20Y, F12Y |
F20Y, F12Y |
1. Order the unit from your local agent (recommended)
2. Add the item to the cart, get an online quote from our website and confirm the order and payment accordingly (recommended and quick)
3. Email us to get a quote
4. Order and pay online from the website if the total amount is under $2,500.00.
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